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Table 1 Summary of preclinical and clinical studies on glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in smoking cessation Comparison of different GLP-1 RAs Among GLP-1 RAs, semaglutide, liraglutide, and tirzepatide are FDA-approved for chronic weight management

Whilst exendin-4-C16 showed minimal reduction in cAMP signalling potency, marked differences were observed for recruitment of key intracellular effectors and trafficking responses, which led to increased insulin secretion with prolonged incubations